DLS analysis: particle size measurements from 0.3 nm to 10 μm
Zeta potential of nanoparticles and colloids using M3-PALS analysis and constant current zeta mode
Extended size range analysis offers improved accuracy for particle sizes above 1 μm, and indicative results above 10 μm

Description

Our entry-level Zetasizer does not compromise on features. The Zetasizer Lab incorporates Adaptive Correlation, M3-PALS and constant current zeta mode. The Zetasizer Lab also ships with ZS Xplorer, easy-to-use analytical software. ZS Xplorer offers instant feedback on data quality, and guidance on how to improve your results. The Zetasizer Lab can be used for many applications, including:

Academia
The Zetasizer Lab is an essential analytical tool for many academic laboratories worldwide, finding use in all applications where particle or molecular size and zeta potential analysis is required. The breadth of applications covered by Zetasizer systems, coupled with tens of thousands of scientific citations, have earned these instruments a central space in many scientific faculties.

Bioscience
Variations in molecule concentration, external temperature, level of agitation and time all impact the stability of biological molecules. Instabilities mainly result in denaturation and aggregation of the molecule through which they can lose their biological function, elicit an immune response and consequently limit its therapeutic viability. Factors affecting therapeutic efficacy and immunogenicity therefore need to be monitored throughout the development pipeline especially at early stages to de-risk the biological drug molecule and limit late-stage failures. The Zetasizer range provides high quality, stability-indicating data for biological drug molecules in a short time frame, enabling this measurement to be implemented throughout the development pipeline.

Food and drink
Zetasizer systems are used to analyze particle size and zeta potential to improve the appearance and taste of foods, drinks and flavorings, and optimize dispersion and emulsion stability to extend product shelf life and improve product performance.

Nanomaterials
Zetasizer measurements of nanoparticle size distribution, dispersion properties, stability and propensity to aggregate are crucial to the design of new nanomaterials. The very large surface area of such materials may result in novel physical and chemical properties, such as increased catalytic activity, improved solubility or unexpected optical or toxicological behavior.

Paints, inks and coatings
Paint, ink and coating formulations must be stable to keep them in an optimum state over time without change or aggregation. Particle size and zeta potential, measured by the Zetasizer instruments, play important roles in determining a product’s properties, such as dispersibility, color, strength, finish, durability and shelf life.

Pharmaceuticals
The correct particle size and zeta potential can help ensure the production of effective therapeutics, delivered safely. Zetasizer systems are used to characterize the stability and quality of dispersions, emulsions and creams, reducing formulation time and speeding new products to market.

Specifications

Particle size and molecular size

Measurement principle	Classical 90° Dynamic Light Scattering
Measurement angle	90°, 13° ⁽¹⁾
Measurement range	0.3 nm to 15 μm ⁽²⁾
Minimum sample volume	3 μL
Concentration range	Minimum Sample Concentration: Blue Label: 1 mg/mL 15 kDa Protein Red Label: 0.3 mg/mL 15 kDa Protein Maximum sample Concentration: ⁽³⁾ 40% w/v

Zeta potential

Measurement principle	Mixed-Mode Measurement phase analysis light scattering (M3-PALS)
Size range	3.8 nm – 100 μm
Minimum sample volume	20 μL ⁽⁴⁾
Concentration range	Red Label: 1 mg/mL ⁽⁵⁾ to 40% w/v ⁽⁶⁾ Blue Label: 10 mg/mL ⁽⁵⁾ to 40% w/v ⁽⁶⁾
Sample conductivity range	Maximum: 260 mS/cm

Static Light Scattering (molecular weight)

Measurement principle	Static Light Scattering with Debye Plot
Molecular weight range	980 Da – 20 MDa
Accuracy	+/- 10% typical

System

Detector	Avalanche Photodiode
Laser safety	He-Ne (633 nm) Blue label: 4 mW Max Red label: 10 mW Max
Temperature control range	0°C to 120°C ⁽⁷⁾
Dimensions (W, D, H)	322 mm x 565 mm x 245 mm
Weight	19 kg
Power	AC 100-240 V, 50-60 Hz, 4.0 A
Power consumption	Max 100 W, Typical 45 W
Ambient conditions	+10°C to +35°C, 35 to 80% RH (Non-condensing)
Interface	USB 2.0 or higher

Footnotes

1 - Water as dispersant
2 - Indicative data available for particle sizes greater than 10 μm when using Extended Size Range analysis and low volume disposable sizing cell accessory
3 - Sample dependent
4 - Using patented diffusion barrier technique
5 - Measured using 15 kDa protein
6 - Measured using bile acid
7 - Dry nitrogen cell purge required for temperatures below dewpoint
8 - Accuracy 0.1°C at 25°C, 0.2°C at 0°C, 0.5°C at 90°C

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