Sysmex Educational Enhancement and Development February 2012

Haemostasis is a complex process that helps to keep the blood in a fluid state and prevent blood loss at the site of injury. While the intact endothelium of blood vessels has an anti-thrombogenic function that prevents blood coagulation, in the case of vessel wall damage, the exposed sub-endothelial components initiate the formation of a clot that will stop blood loss.

Sysmex Educational Enhancement and Development June 2012

The detection of blast cells in the peripheral blood is considered extremely important, and great responsibility is placed on the investigating laboratory. As well as information on the physiology, this SEED article describes the possible causes of the release of blast cells into the blood, the characteristics by which they can be identified and how further diagnosis is carried out.

This SEED article is meant to explain the findings focused on cell count and differentiation for pleural, ascitic, cerebrospinal and synovial fluid as well as for CAPD. Traditionally, body fluid counts are performed by manual counting under a microscope using a haemocytometer, but laboratories now have the option of automating their manual processes using automated haematology or urinalysis analysers. This SEED summarises the advantages and disadvantages of haemocytometry and Sysmex analysers and explains briefly the XN-BF mode.

In this clinical case report a patient presented with a dimorphic RBC population after having received multiple RBC concentrates. The two populations, one resulting from the donor cells, can be identified from two distinct peaks in the RBC histogram.

Being diagnosed with haematologic malignancy actually happens either because the patient presents with certain symptoms or – as is becoming increasingly common – there are incidental findings during routine blood screening on modern haematology analysers. This white paper aims to describe how parameters of a complete blood count may reveal significant abnormalities and improve the incidental findings of suspected haematologic samples early on.

Chronic kidney disease (CKD) is a severe complication in context of various civilisation diseases, such as diabetes, hypertension, and obesity. With increasing treatment cost along the progression of CKD towards end-stage renal failure (ESRF) and the need for renal replacement therapies, CKD is not only a driver of premature mortality and diminished quality of life of affected individuals, but also puts significant burden on the society and healthcare expenditures. The early detection of kidney damage through a frequent screening of risk patients could help to fight the burden of CKD. Cost-efficient routine urinalysis data could play a vital role in providing valuable information for screening, diagnosing, and monitoring of renal disorders.

The second part of the SEED article explains in detail the process of HSCT with its phases and requirements.